Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC063
Test administered by neuromedic@manusdevices.net
Test date and time 2023-02-01 11:37
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment madopar 250mg 3x1\2 pk merz 100mg 2x1 mirapexin 3,75mg

Overall Assessment

non PD

Subject performance similar to non PD population

Clinical context

In the clinical reference population, 7 individuals with a value less than 0.53 were subsequently diagnosed with PD. That is, 16.67% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.53 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 33, 'TN': 25, 'TP': 9, 'FP': 5}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 31, 'TN': 26, 'TP': 11, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 10, 'TN': 8, 'TP': 32, 'FP': 22}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 20, 'TN': 12, 'TP': 22, 'FP': 18}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 7.348
timePerCircleCoV 0.16607
timePerCircleSlope -0.0462876
meanError 1.52512
tremorFreq 6.25
tremorRelPower 71.7568
tremorGyroAmpMean 0.230784
tremorGyroAmpSlope 0.000199202
tremorGyroAmpCoV 0.442692
tremorCoordAmpMean 0.266834
tremorCoordAmpSlope -0.00226768
tremorCoordAmpCoV 0.523649
tremorAccAmpMean 0.250074
tremorAccAmpSlope -0.00177874
tremorAccAmpCoV 0.489068
tremorPcRelVar 0.689886
tremorPcX -0.853854
tremorPcY 0.520513

Circle Segment 1

Duration 9.96 s, Accuracy Estimate 1.228 (lower is better)

Circle Segment 2

Duration 7.92 s, Accuracy Estimate 1.721 (lower is better)

Circle Segment 3

Duration 8.52 s, Accuracy Estimate 1.387 (lower is better)

Circle Segment 4

Duration 7.76 s, Accuracy Estimate 1.68 (lower is better)

Circle Segment 5

Duration 7.24 s, Accuracy Estimate 1.314 (lower is better)

Circle Segment 6

Duration 6.4 s, Accuracy Estimate 1.478 (lower is better)

Circle Segment 7

Duration 5.92 s, Accuracy Estimate 1.681 (lower is better)

Circle Segment 8

Duration 6.68 s, Accuracy Estimate 1.383 (lower is better)

Circle Segment 9

Duration 6.6 s, Accuracy Estimate 1.455 (lower is better)

Circle Segment 10

Duration 6.48 s, Accuracy Estimate 1.926 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 17.924
timePerSpiralCoV 0.0784888
timePerSpiralSlope -0.0115099
meanError 2.03133
tremorFreq 5.76172
tremorRelPower 66.5081
tremorGyroAmpMean 0.294864
tremorGyroAmpSlope 0.00185435
tremorGyroAmpCoV 0.315172
tremorCoordAmpMean 0.323113
tremorCoordAmpSlope 0.00100881
tremorCoordAmpCoV 0.371542
tremorAccAmpMean 0.292655
tremorAccAmpSlope 0.00154015
tremorAccAmpCoV 0.324306
tremorPcRelVar 0.74585
tremorPcX 0.508002
tremorPcY -0.861356

Spiral Segment 1

Duration 17.88 s, Accuracy Estimate 1.898 (lower is better)

Spiral Segment 2

Duration 19.8 s, Accuracy Estimate 2.085 (lower is better)

Spiral Segment 3

Duration 17.96 s, Accuracy Estimate 1.845 (lower is better)

Spiral Segment 4

Duration 19.56 s, Accuracy Estimate 2.149 (lower is better)

Spiral Segment 5

Duration 18.96 s, Accuracy Estimate 2.041 (lower is better)

Spiral Segment 6

Duration 15.12 s, Accuracy Estimate 2.263 (lower is better)

Spiral Segment 7

Duration 17.52 s, Accuracy Estimate 2.019 (lower is better)

Spiral Segment 8

Duration 17.44 s, Accuracy Estimate 2.159 (lower is better)

Spiral Segment 9

Duration 18.48 s, Accuracy Estimate 1.897 (lower is better)

Spiral Segment 10

Duration 16.52 s, Accuracy Estimate 1.958 (lower is better)

Elel

eDurationMean 0.340962
eDurationStd 0.0930916
eDurationStdnorm 0.273027
eDurationMedian 0.3275
eDurationQuartdelta 0.125
eDurationQuartdeltanorm 0.381679
eDurationKurt 3.31286
eDurationTrenddiff -0.125
eDurationTrendratio 0.679487
eWidthMean 3.96
eWidthStd 1.47241
eWidthStdnorm 0.371822
eWidthMedian 3.6855
eWidthQuartdelta 1.287
eWidthQuartdeltanorm 0.349206
eWidthKurt 4.85766
eWidthTrenddiff -0.585
eWidthTrendratio 0.852941
eHeightMean 8.2395
eHeightStd 4.24917
eHeightStdnorm 0.515707
eHeightMedian 6.7275
eHeightQuartdelta 1.755
eHeightQuartdeltanorm 0.26087
eHeightKurt 5.86656
eHeightTrenddiff -1.521
eHeightTrendratio 0.796875
eAspectMean 0.51936
eAspectStd 0.143207
eAspectStdnorm 0.275738
eAspectMedian 0.558741
eAspectQuartdelta 0.173846
eAspectQuartdeltanorm 0.311139
eAspectKurt 5.05281
eAspectTrenddiff 0.124527
eAspectTrendratio 1.25684
eSlantMean -0.0477624
eSlantStd 0.22762
eSlantStdnorm -4.76568
eSlantMedian -0.0706622
eSlantQuartdelta 0.385773
eSlantQuartdeltanorm -5.4594
eSlantKurt 1.86776
eSlantTrenddiff 0.345358
eRtopMean 0.741747
eRtopStd 0.194698
eRtopStdnorm 0.262486
eRtopMedian 0.742396
eRtopQuartdelta 0.31565
eRtopQuartdeltanorm 0.425177
eRtopKurt 2.08984
eRtopTrenddiff 0.259524
eRbotMean 0.986416
eRbotStd 0.854544
eRbotStdnorm 0.866311
eRbotMedian 0.871429
eRbotQuartdelta 0.512644
eRbotQuartdeltanorm 0.58828
eRbotKurt 17.201
eRbotTrenddiff -0.44721
eRrightMean 0.899162
eRrightStd 0.119071
eRrightStdnorm 0.132424
eRrightMedian 0.951061
eRrightQuartdelta 0.184615
eRrightQuartdeltanorm 0.194115
eRrightKurt 2.49562
eRrightTrenddiff 0.10276
eRleftMean 0.416676
eRleftStd 0.182665
eRleftStdnorm 0.438387
eRleftMedian 0.415385
eRleftQuartdelta 0.196566
eRleftQuartdeltanorm 0.473215
eRleftKurt 3.18061
eRleftTrenddiff -0.139617
lDurationMean 0.38413
lDurationStd 0.0676833
lDurationStdnorm 0.176199
lDurationMedian 0.36
lDurationQuartdelta 0.095
lDurationQuartdeltanorm 0.263889
lDurationKurt 2.67308
lDurationTrenddiff -0.08
lDurationTrendratio 0.816092
lWidthMean 5.08696
lWidthStd 1.32834
lWidthStdnorm 0.261126
lWidthMedian 4.914
lWidthQuartdelta 2.19375
lWidthQuartdeltanorm 0.446429
lWidthKurt 2.49837
lWidthTrenddiff -0.936
lWidthTrendratio 0.833333
lHeightMean 14.4215
lHeightStd 4.33535
lHeightStdnorm 0.300617
lHeightMedian 13.221
lHeightQuartdelta 5.76225
lHeightQuartdeltanorm 0.435841
lHeightKurt 2.63727
lHeightTrenddiff -5.499
lHeightTrendratio 0.680272
lAspectMean 0.375574
lAspectStd 0.141079
lAspectStdnorm 0.375637
lAspectMedian 0.340136
lAspectQuartdelta 0.142379
lAspectQuartdeltanorm 0.418594
lAspectKurt 10.3615
lAspectTrenddiff 0.0734694
lAspectTrendratio 1.225
lSlantMean 0.0490176
lSlantStd 0.126035
lSlantStdnorm 2.57123
lSlantMedian 0.0391061
lSlantQuartdelta 0.120361
lSlantQuartdeltanorm 3.07779
lSlantKurt 3.15236
lSlantTrenddiff 0.0450251
lRtopMean 0.820958
lRtopStd 0.178947
lRtopStdnorm 0.217973
lRtopMedian 0.84058
lRtopQuartdelta 0.19136
lRtopQuartdeltanorm 0.227652
lRtopKurt 4.74896
lRtopTrenddiff 0.0595238
lRbotMean 0.700123
lRbotStd 0.284542
lRbotStdnorm 0.406418
lRbotMedian 0.707317
lRbotQuartdelta 0.389738
lRbotQuartdeltanorm 0.55101
lRbotKurt 2.35153
lRbotTrenddiff -0.0421607
lRrightMean 0.935678
lRrightStd 0.0620108
lRrightStdnorm 0.0662737
lRrightMedian 0.935484
lRrightQuartdelta 0.107003
lRrightQuartdeltanorm 0.114382
lRrightKurt 2.13537
lRrightTrenddiff 0.0938503
lRleftMean 0.324895
lRleftStd 0.129806
lRleftStdnorm 0.399533
lRleftMedian 0.31405
lRleftQuartdelta 0.148684
lRleftQuartdeltanorm 0.47344
lRleftKurt 3.19615
lRleftTrenddiff -0.0649988

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.646648
sumTouchScores 12.2863
meanMovementTime 0.776944
numTouches 19
undershootPercentage 0
overshootPercentage 36.8421

FITTS Long Modified

meanTouchScore 0.807779
sumTouchScores 15.3478
meanMovementTime 1.00722
numTouches 19
undershootPercentage 5.26316
overshootPercentage 0

fitts_long data not in signals file.

ZigZag

numZigzags 5
timePerZigzagMean 16.192
timePerZigzagCoV 0.102979
timePerZigzagSlope -0.0531126
meanError 2.43514
tremorFreq 6.05469
tremorRelPower 69.4534
tremorGyroAmpMean 0.313701
tremorGyroAmpSlope 0.000585665
tremorGyroAmpCoV 0.301297
tremorCoordAmpMean 0.345171
tremorCoordAmpSlope 4.00854e-05
tremorCoordAmpCoV 0.31236
tremorAccAmpMean 0.308339
tremorAccAmpSlope 0.000569488
tremorAccAmpCoV 0.321268
tremorPcRelVar 0.834265
tremorPcX 0.684661
tremorPcY 0.728861

ZigZag Segment 1

Duration 17.36 s, Accuracy Estimate 2.888 (lower is better)

ZigZag Segment 2

Duration 16.68 s, Accuracy Estimate 2.202 (lower is better)

ZigZag Segment 3

Duration 17.56 s, Accuracy Estimate 2.211 (lower is better)

ZigZag Segment 4

Duration 15.92 s, Accuracy Estimate 2.387 (lower is better)

ZigZag Segment 5

Duration 13.44 s, Accuracy Estimate 2.488 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 9.696
timePerZigzagCoV 0.221135
timePerZigzagSlope -0.105198
zigzagHeightMean 72.9502
zigzagHeightCoV 0.0722935
zigzagHeightSlope 0.0252303
meanError 0.0377596
tremorFreq 5.85938
tremorRelPower 68.182
tremorGyroAmpMean 0.368851
tremorGyroAmpSlope 0.0168743
tremorGyroAmpCoV 0.272292
tremorCoordAmpMean 0.395328
tremorCoordAmpSlope 0.0107344
tremorCoordAmpCoV 0.252044
tremorAccAmpMean 0.334008
tremorAccAmpSlope 0.0121104
tremorAccAmpCoV 0.238708
tremorPcRelVar 0.786126
tremorPcX -0.5244
tremorPcY -0.851472

ZigZag Offset Segment 1

Duration 13.52 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 2

Duration 8.84 s, Accuracy Estimate 0.036 (lower is better)

ZigZag Offset Segment 3

Duration 8.92 s, Accuracy Estimate 0.033 (lower is better)

ZigZag Offset Segment 4

Duration 8.72 s, Accuracy Estimate 0.043 (lower is better)

ZigZag Offset Segment 5

Duration 8.48 s, Accuracy Estimate 0.04 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.78}
RanFor {‘RanFor_class’: ‘NOT PD’, ‘RanFor_score’: 0.53}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.8773952138478349}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8781006639228239}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.4877726555217643}